AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |
Back to Blog
Platinum notes 4.0 vip11/13/2022 Because of the differences in genetics, physiology, pathology, diet, living environment, and nutritional status, the same drug regimen may not be suitable for every ethnic groups. The total population of the Wa ethnic group in China is 429,709, based on the data of the sixth nationwide population census in 2010. The Wa people reside mainly in the Yunnan Province of Southwestern China. There are 56 ethnic groups recognized by the People's Republic of China, and different ethnic groups have different reactions to drugs. The PharmGKB database also integrates information from the Clinical Pharmacogenetics Implementation Consortium (CPIC) to provide drug dosage guidance based on individual genotypes. The PharmGKB database describes the connection between genes, diseases and drugs and provides various forms of knowledge, including the abstracts of very important pharmacogene (VIP), drug pathway diagrams and selected literature notes. PharmGKB, the Pharmacogenomics Knowledge Base ( ) is dedicated to disseminating information on how genetic variation causes variation in drug response. At present, it is necessary to integrate genomic data into the benefit and risk assessment of daily treatment so that individualised treatment has a certain possibility to vary from person to person. Over the past 60 years, pharmacogenomics has been used to determine the genetic determinants of drug effects and to maximize drug efficacy and minimize ADR. Therefore, it can be used for individualised drug therapy. Pharmacogenomics is a discipline that studies how genetic factors affect the responses of individuals to drug therapy and transforms the drug responses of individuals into a molecular diagnosis. Increasing evidence shows that genetic differences between individuals are an important factor to ADR. The study results will have an effect on supplementing the pharmacogenomics information for the Wa population and providing a theoretical basis for individualised medication for the Wa population.Īdverse drug reaction (ADR) having the ability of causing severe morbidity and mortality among patients is a major concern in clinical practice and the pharmaceutical industry. Our research results show that there is a significant difference in the distribution of VIP variants between the Wa ethnic group and the other 26 populations. Additionally, the difference between the Wa ethnic group and East Asian populations, such as CDX, CHB, and CHS, was the smallest. The genotype frequencies rs4291-TA, rs3093105-CA, rs1051298-AG and rs1065852-GA were higher than those of the other populations, and the allele distributions of rs4291-T and rs3093105-C were significantly different. The study results showed that compared with the other 26 population groups, five variants rs776746 ( CYP3A5), rs4291 ( ACE), rs3093105 (CYP4F2), rs1051298 ( SLC19A1), and rs1065852 ( CYP2D6) had higher frequencies in the Wa population. Next, χ 2 test was used to determine the significant points between these populations. We also compared the genotype frequency and allele distribution of VIP variants between Wa population and the other 26 populations from the 1000 Genomes Project ( ). In this study, we recruited 200 unrelated healthy Wa adults from the Yunnan province of China, selected 52 VIP variants from the PharmGKB for genotyping. This study aimed to uncover the significantly different loci in the Wa population in Yunnan Province of China from the perspective of pharmacogenomics, to provide a theoretical basis for the future medication guidance, and to ultimately achieve the best treatment in the future. The information of Chinese ethnic minorities such as the Wa ethnic group is scarce. Very important pharmacogenetic (VIP) variants mean that genes or variants play important and vital roles in drug response, which have been listed in pharmacogenomics databases, such as Pharmacogenomics Knowledge Base (PharmGKB). With the development of pharmacogenetics and pharmacogenomics, the differences in drug response between different races seem to be mainly caused by the genetic diversity of pharmacodynamics and pharmacokinetics genes. The variation of drug responses and target does among individuals is mostly determined by genes.
0 Comments
Read More
Leave a Reply. |